| Cat. No. |
Product Name |
Information |
| PC-45136 |
Dofequidar
P-gp inhibitor
|
Dofequidar (MS-209) is an orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR. |
| PC-42403 |
Polyoxyethylene stearate
P-gp inhibitor
|
Polyoxyethylene stearate (PS40) is a non-ionic emulsifying agent that can modulate multidrug resistance and enhances antitumor activity of vinblastine sulfate by modulating substrate-stimulated P-gp ATPase activity. |
| PC-45207 |
Valspodar
MDR1 inhibitor
|
Valspodar (PSC-833) is a highly potent multidrug-resistance modifier that acts as a P-glycoprotein MDR1 inhibitor, exhibits effectivity at preventing cancer cell resistance to chemotherapeutics. |
| PC-23219 |
WS-917
ABCB1 modulator
|
WS-917 is a highly potent and orally available ABCB1 (MDR1, P-glycoprotein (P-gp)) modulator, enhance ABCB1 ATPase activity, exhibits a significant contributor to heightened sensitization of human colorectal adenocarcinoma cells (SW620/Ad300) to paclitaxel (IC50=5 nM). |
| PC-22756 |
ZW-1226
MRP1 inhibitor
|
ZW-1226 is a deazaflavin analog and potent inhibitor of multidrug resistance-associated protein 1 (MRP1), inhibits MRP1-mediated E217βG uptake with IC50 of 0.5 uM in vesicular transport assay. |
| PC-21827 |
VX-853
MDR modulator
|
Timcodar (VX-853) is small molecule modulator of P-glycoprotein (Pgp) and multidrug resistance protein (MRP-1), directly blockes EtBr efflux in S. aureus. |
| PC-21826 |
VX-710
MDR modulator
|
Biricodar (VX-710) is small molecule modulator of P-glycoprotein (Pgp) and multidrug resistance protein (MRP-1), modulates Pgp, MRP-1, and BCRP(R482), enhances chemosensitivity in resistant cells. |
| PC-42649 |
Tariquidar methanesulfonate hydrate
|
A potent, specific P-gp inhibitor with Kd of 5.1 nM. |
