Zosuquidar trihydrochloride (LY335979) | P-gp inhibitor

Chemical Structure : Zosuquidar trihydrochloride

CAS No.: 167465-36-3

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Zosuquidar trihydrochloride (LY-335979 trihydrochloride, LY335979)

货号: PC-45836Not For Human Use, Lab Use Only.

Zosuquidar trihydrochloride (LY335979) is a potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

Zosuquidar trihydrochloride (LY335979) is a potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM.
Zosuquidar trihydrochloride (LY-335979) fully restores sensitivity to vinblastine, doxorubicin, etoposide, and Taxol in CEM/VLB100 cells at 0.1 uM.
Zosuquidar trihydrochloride (LY-335979) enhances the antitumor activity of Taxol in a MDR human non-small cell lung carcinoma nude mouse xenograft model.

物理化学性质&存储条件

分子量	636.9871
分子式	C32H34Cl3F2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Piperazineethanol, 4-[(1a.alpha.,6.alpha.,10b.alpha.)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-.alpha.-[(5-quinolinyloxy)methyl]-, hydrochloride (1:3), (.alpha.R)-

参考文献

1. Slate DL, et al. Anticancer Res. 1995 May-Jun;15(3):811-4.

2. Dantzig AH, et al. Cancer Res. 1996 Sep 15;56(18):4171-9.

3. Dantzig AH, et al. J Pharmacol Exp Ther. 1999 Aug;290(2):854-62.

Zosuquidar trihydrochloride (LY-335979 trihydrochloride, LY335979)

生物&药学活性

物理化学性质&存储条件

参考文献

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Zosuquidar trihydrochloride (LY-335979 trihydrochloride, LY335979)

生物&药学活性

物理化学性质&存储条件

参考文献

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