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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-P-glycoprotein (P-gp)-Polyoxyethylene stearate
Polyoxyethylene stearate

Chemical Structure : Polyoxyethylene stearate

CAS No.: 9004-99-3

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Polyoxyethylene stearate (PS40)

货号: PC-42403Not For Human Use, Lab Use Only.

Polyoxyethylene stearate (PS40) is a non-ionic emulsifying agent that can modulate multidrug resistance and enhances antitumor activity of vinblastine sulfate by modulating substrate-stimulated P-gp ATPase activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Polyoxyethylene stearate (PS40) is a non-ionic emulsifying agent that can modulate multidrug resistance and enhances antitumor activity of vinblastine sulfate by modulating substrate-stimulated P-gp ATPase activity.
Polyoxyethylene stearate inhibits P-gp mediated efflux in a concentration-dependent manner in Caco-2 cells.
Polyoxyethylene stearate also shows potential inhibitory activitites agasint CYP2C9 and CYP2C19.

物理化学性质&存储条件

分子量 725.00284
分子式 (C2H4O)10C18H36O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 49 mg/mL
Chemical Name/SMILES

Poly(oxy-1,2-ethanediyl), α-(1-oxooctadecyl)-ω-hydroxy-

参考文献

1. Cutler RR, et al. Tubercle. 1987 Sep;68(3):209-20.

2. Luo L, et al. AAPS J. 2007 Oct 5;9(3):E329-35.

3. Zhu S, et al. Eur J Pharm Sci. 2009 Jul 12;37(5):573-80.

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