Elacridar | P-gp inhibitor | Probechem Biochemicals

Chemical Structure : Elacridar

CAS No.: 143664-11-3

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Elacridar (GF-120918,GW-0918, GG-918)

货号: PC-45887Not For Human Use, Lab Use Only.

Elacridar (GF120918, GW-0918) is a potent inhibitor of multidrug resistance (MDR, P-gp) that fully reverses multidrug resistance CHRC5, OV1/DXR and MCF7/ADR cells to the cytotoxicity of doxorubicin and vincristine with IC50 of 0.02 uM.

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25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

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生物&药学活性

Elacridar (GF120918, GW-0918) is a potent inhibitor of multidrug resistance (MDR, P-gp) that fully reverses multidrug resistance CHRC5, OV1/DXR and MCF7/ADR cells to the cytotoxicity of doxorubicin and vincristine with IC50 of 0.02 uM.
Elacridar (GF120918, GW-0918) effectively competes with [3H]azidopine for binding P-glycoprotein.
Elacridar (GF120918, GW-0918) restores sensitivity of the tumor to a single dose of doxorubicin in mice; orally bioavailable.

物理化学性质&存储条件

分子量	563.6429
分子式	C34H33N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Acridinecarboxamide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-

参考文献

1. Hyafil F, et al. Cancer Res. 1993 Oct 1;53(19):4595-602.

2. den Ouden D, et al. Leukemia. 1996 Dec;10(12):1930-6.

3. Witherspoon SM, et al. Clin Cancer Res. 1996 Jan;2(1):7-12.

Elacridar (GF-120918,GW-0918, GG-918)

生物&药学活性

物理化学性质&存储条件

参考文献

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Elacridar (GF-120918,GW-0918, GG-918)

生物&药学活性

物理化学性质&存储条件

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