Zosuquidar | P-gp inhibitor | Probechem Biochemicals

Chemical Structure : Zosuquidar

CAS No.: 167354-41-8

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Zosuquidar (LY335979)

货号: PC-23700Not For Human Use, Lab Use Only.

Zosuquidar (LY335979) is a potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3580	In stock
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100 mg		Get quote

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生物&药学活性

Zosuquidar (LY335979) is a potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM.
Zosuquidar (LY335979) fully restores sensitivity to vinblastine, doxorubicin, etoposide, and Taxol in CEM/VLB100 cells at 0.1 uM.
Zosuquidar (LY335979) enhances the antitumor activity of Taxol in a MDR human non-small cell lung carcinoma nude mouse xenograft model.

物理化学性质&存储条件

分子量	527.62
分子式	C32H31F2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(4-((1aR,6r,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c][7]annulen-6-yl)piperazin-1-yl)-3-(quinolin-5-yloxy)propan-2-ol

参考文献

1. Slate DL, et al. Anticancer Res. 1995 May-Jun;15(3):811-4.

2. Dantzig AH, et al. Cancer Res. 1996 Sep 15;56(18):4171-9.

3. Dantzig AH, et al. J Pharmacol Exp Ther. 1999 Aug;290(2):854-62.

Zosuquidar (LY335979)

生物&药学活性

物理化学性质&存储条件

参考文献

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Zosuquidar (LY335979)

生物&药学活性

物理化学性质&存储条件

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