| Cat. No. |
Product Name |
Information |
| PC-60755 |
SB-649868
OX1R/OX2R antagonist
|
SB-649868 is a potent, selective, orally bioavailable, dual orexin OX1/OX2R antagonist with pKi of 9.4 and 9.5 respectively. |
| PC-60752 |
GSK-1059865
OX1R antagonist
|
GSK-1059865 is a highly potent, selective orexin-1 receptor (OX1R) antagonist with IC50 of 5.0 and 6.4 nM for hOX1R and rOX1R, respectively. |
| PC-60727 |
ACT-541468
Orexin receptor antagonist
|
ACT-541468 (Nemorexant) is a potent, selective, dual orexin receptor 1 and 2 (OX1 and OX2) antagonist with Kb of 0.52 and 0.78 nM, respectively. |
| PC-70015 |
JNJ-10397049
OX2R antagonist
|
JNJ-10397049 is a potent, selective, and bioavailable OX2 receptor (OX2R) antagonist with Kb of 4.5 nM. |
| PC-60062 |
Suvorexant
Orexin receptor antagonist
|
Suvorexant (MK-4305, MK4305) is a potent, CNS penetrant, orally available, dual orexin receptor antagonist with Ki of 0.55 and 0.35 nM for OX1R and OX2R, respectively. |
| PC-42731 |
SB-334867 free base
OX1R inhibitor
|
SB-334867 is the first selective Orexin-1 receptor (OX1R) antagonist with pKb of 7.4, displays 50-fold selectivity over OX2R (pKb 5.7). |
| PC-42730 |
SB-334867
OX1R inhibitor
|
SB-334867 (SB 334867A) is the first selective Orexin-1 receptor (OX1R) antagonist with pKb of 7.4. |
| PC-45062 |
Lemborexant
OX1R/OX2R antagonist
|
Lemborexant (E2006) is an orally active, potent, selective, dual Orexin receptor OX1/2 antagonist with binding Ki of 6/3 nM, respectively. |
| PC-45747 |
MK-1064
OX2R inhibitor
|
MK-1064 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki/IC50 of 0.5/18 nM. |
| PC-45951 |
SB-408124
OX1R antagonist
|
SB-408124 is a potent, selective OX1 receptor (OX1R) antagonist with Ki of 57 nM (whole cell assay), and 27 nM (cell membrane-based SPA assay). |
| PC-42159 |
TCS-OX2-29
OX2R antagonist
|
TCS-OX2-29 is a potent, selective orexin-2 receptor (OX2R) antagonist with IC50 of 40 nM. |
| PC-42732 |
SB-674042
OX1R antagonist
|
SB-674042 is a potent, selective nonpeptide Orexin 1 receptor (OX1R) antagonist with Ki of 26.9 nM in the membrane SPA format, and Ki of 57 nM in the whole-cell assay. |
