SB-649868 | OX1R/OX2R antagonist | Probechem Biochemicals

Chemical Structure : SB-649868

CAS No.: 380899-24-1

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SB-649868 (SB 649868, SB649868)

货号: PC-60755Not For Human Use, Lab Use Only.

SB-649868 is a potent, selective, orally bioavailable, dual orexin OX1/OX2R antagonist with pKi of 9.4 and 9.5 respectively.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

SB-649868 is a potent, selective, orally bioavailable, dual orexin OX1/OX2R antagonist with pKi of 9.4 and 9.5 respectively.
SB-649868 displays >1,000-fold selectivity for the orexin target receptors in a broad panel of GPCRs, ion channels and enzymes.
SB-649868 demonstrates high effectivity in pre-clinical model of sleep disorders

物理化学性质&存储条件

分子量	477.554
分子式	C26H24FN3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-((1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)piperidin-2-yl)methyl)benzofuran-4-carboxamide

参考文献

1. Renzulli C, et al. Drug Metab Dispos. 2011 Feb;39(2):215-27.

2. Bettica P, et al .Neuropsychopharmacology. 2012 Apr;37(5):1224-33.

3. Piccoli L, et al. Neuropsychopharmacology. 2012 Aug;37(9):1999-2011.

4. Di Fabio R, et al. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5562-7.

SB-649868 (SB 649868, SB649868)

生物&药学活性

物理化学性质&存储条件

参考文献

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SB-649868 (SB 649868, SB649868)

生物&药学活性

物理化学性质&存储条件

参考文献

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