ACT-541468 |CAS:1505484-82-1 Probechem Biochemicals

Chemical Structure : ACT-541468

CAS No.: 1505484-82-1

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ACT-541468 (Nemorexant;ACT541468;DORA)

货号: PC-60727Not For Human Use, Lab Use Only.

ACT-541468 (Nemorexant) is a potent, selective, dual orexin receptor 1 and 2 (OX1 and OX2) antagonist with Kb of 0.52 and 0.78 nM, respectively.

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10 mg	￥5580	In stock
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生物&药学活性

ACT-541468 (Nemorexant) is a potent, selective, dual orexin receptor 1 and 2 (OX1 and OX2) antagonist with Kb of 0.52 and 0.78 nM, respectively.
ACT-541468 displays high selectivity over a panel of 130 central and peripheral pharmacological targets.
ACT-541468 shows potential for treatment of insomnia disorder.

物理化学性质&存储条件

分子量	450.927
分子式	C23H23ClN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-(2-(5-chloro-4-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

参考文献

1. Treiber A, et al. J Pharmacol Exp Ther. 2017 Sep;362(3):489-503.

ACT-541468 (Nemorexant;ACT541468;DORA)

生物&药学活性

物理化学性质&存储条件

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ACT-541468 (Nemorexant;ACT541468;DORA)

生物&药学活性

物理化学性质&存储条件

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