JNJ-10397049 | OX2R antagonist | Probechem Biochemicals

Chemical Structure : JNJ-10397049

CAS No.: 708275-58-5

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JNJ-10397049 (JNJ 10397049)

货号: PC-70015Not For Human Use, Lab Use Only.

JNJ-10397049 is a potent, selective, and bioavailable OX2 receptor (OX2R) antagonist with Kb of 4.5 nM.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

JNJ-10397049 is a potent, selective, and bioavailable OX2 receptor (OX2R) antagonist with Kb of 4.5 nM.
JNJ-10397049 displays >200-fold selectivity over OX1R (Kb=1.1 uM), and has no significant affinity for over 50 other neurotransmitters or neuropeptide receptors.
JNJ-10397049 decreases the latency for persistent sleep and increases nonrapid eye movement and rapid eye movement sleep time in rats
JNJ-10397049 attenuates D-amphetamine-induced relative cerebrovascular signal, with prominent cortical involvement in rat brains.

物理化学性质&存储条件

分子量	484.2
分子式	C19H20Br2N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2,4-dibromophenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)urea

参考文献

1. Dugovic C, et al. J Pharmacol Exp Ther. 2009 Jul;330(1):142-51.

2. Faedo S, et al. Eur J Pharmacol. 2012 Oct 5;692(1-3):1-9.

3. Gozzi A, et al. PLoS One. 2011 Jan 28;6(1):e16406.

JNJ-10397049 (JNJ 10397049)

生物&药学活性

物理化学性质&存储条件

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JNJ-10397049 (JNJ 10397049)

生物&药学活性

物理化学性质&存储条件

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