Suvorexant (MK-4305) | Orexin receptor antagonist | Probechem Biochemicals

Chemical Structure : Suvorexant

加入收藏

Suvorexant (MK-4305, MK4305)

货号: PC-60062Not For Human Use, Lab Use Only.

Suvorexant (MK-4305, MK4305) is a potent, CNS penetrant, orally available, dual orexin receptor antagonist with Ki of 0.55 and 0.35 nM for OX1R and OX2R, respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Suvorexant (MK-4305, MK4305) is a potent, CNS penetrant, orally available, dual orexin receptor antagonist with Ki of 0.55 and 0.35 nM for OX1R and OX2R, respectively.
Suvorexant significantly and dose-dependently reduces locomotor activity and promotes sleep in rats.

物理化学性质&存储条件

分子量	450.92
分子式	C23H23ClN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-(4-(5-chlorobenzo[d]oxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

参考文献

1. Cox CD, et al. J Med Chem. 2010 Jul 22;53(14):5320-32.

2. Winrow CJ, et al. J Neurogenet. 2011 Mar;25(1-2):52-61.

3. Sun H, et al. Sleep. 2013 Feb 1;36(2):259-67.

4. Hopkins CR. ACS Chem Neurosci. 2012 Sep 19;3(9):647-8.

Suvorexant (MK-4305, MK4305)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Suvorexant (MK-4305, MK4305)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.