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首页-小分子抑制剂&激动剂-GPCR-Orexin Receptor-Suvorexant
Suvorexant

Chemical Structure : Suvorexant

CAS No.: 1030377-33-3

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Suvorexant (MK-4305, MK4305)

货号: PC-60062Not For Human Use, Lab Use Only.

Suvorexant (MK-4305, MK4305) is a potent, CNS penetrant, orally available, dual orexin receptor antagonist with Ki of 0.55 and 0.35 nM for OX1R and OX2R, respectively.

规格 价格 库存 数量
5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4880 In stock
100 mg Get quote
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1 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Suvorexant (MK-4305, MK4305) is a potent, CNS penetrant, orally available, dual orexin receptor antagonist with Ki of 0.55 and 0.35 nM for OX1R and OX2R, respectively.
Suvorexant significantly and dose-dependently reduces locomotor activity and promotes sleep in rats.

物理化学性质&存储条件

分子量 450.92
分子式 C23H23ClN6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-(4-(5-chlorobenzo[d]oxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

参考文献

1. Cox CD, et al. J Med Chem. 2010 Jul 22;53(14):5320-32.

2. Winrow CJ, et al. J Neurogenet. 2011 Mar;25(1-2):52-61.

3. Sun H, et al. Sleep. 2013 Feb 1;36(2):259-67.

4. Hopkins CR. ACS Chem Neurosci. 2012 Sep 19;3(9):647-8.

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