Isocitrate Dehydrogenase (IDH) (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-72650	NCATS-SM5637 mutant IDH1 inhibitor	NCATS-SM5637 (NSC 791985) is a potent, selective mutant IDH1 inhibitor with IC50 of 81/72 nM for IDH1 mutant R132H/R132C, respctively.
PC-38189	DS-1001b mutant IDH1 inhibitor	DS-1001b (DS1001b) is a potent, selective, BBB-permeable and orally bioavailable mutant IDH1 inhibitor with IC50 of 8.4/11 nM against IDH1 R132H/R132C mutants.
PC-38188	DS-1001b free base mutant IDH1 inhibitor	DS-1001b free base (DS1001b, Safusidenib) is a potent, selective, BBB-permeable and orally bioavailable mutant IDH1 inhibitor with IC50 of 8.4/11 nM against IDH1 R132H/R132C mutants.
PC-35975	Olutasidenib mutant IDH1 inhibitor	Olutasidenib (FT-2102) is a potent, orally bioavailable, brain penetrant, and selective mIDH1 inhibitor with IC50 of 21.2 nM and 114 nM for IDH1 mutant R132H and R132C, respectively.
PC-35209	BRD2879 IDH1 R132H inhibitor	BRD2879 (BRD-2879) is a potent, selective inhibitor of IDH1-R132H mutant with IC50 of 50 nM, inhibits cell-based production of R-2HG with EC50 of 0.3 uM.
PC-35208	mutant IDH1 inhibitor VVS mutant IDH1 inhibitor	mutant IDH1 inhibitor VVS is a potent, selective c with nanomolar potency against both IDH1 R132H and IDH1 R132C, efficiently suppresses the cell-based production of D-2-HG in an HEK293 mutant embryonic kidney cell line.
PC-35207	SYC-435 mutant IDH1 inhibitor	SYC-435 (SYC435) is a potent inhibitor of mutant IDH1, binds at the isocitrate pocket of mutated IDH1 with Ki values of 190 nM against IDH1 R132H and 120 nM against IDH1 R132C.
PC-35206	AGI-14100 mutant IDH1 inhibitor	AGI-14100 (AGI14100) is a novel potent and selective, orally available IDH1 mutant inhibitor, inhibits cell proliferation (human cell lines transfected with IDH1 R132H) with IC50 values of 0.76 nM (HT-1080), 0.74 nM (U87-MG) and 1.75 nM (TF1).
PC-35173	IDH889 mutant IDH1 inhibitor	IDH889 (IDH-889) is a potent, selective, brain penetrant, orally active IDH1 R132H mutant with IC50 of 20 nM, with good overall selectivity vs the wt IDH1.
PC-35142	MRK-A mutant IDH1 inhibitor	MRK-A is a potent, highly selective, brain penetrant inhibitor of mutant IDH1 with IC50 of 5 nM, displays a 10,000-fold mutant to wildtype selectivity ratio.
PC-35141	HMS-101 mutant IDH1 inhibitor	HMS-101 (HMS101) is a potent, selective mutant IDH1 inhibitor, the IC50 is significantly lower in mouse bone marrow cells transduced with IDH1mut compared with IDH1wt (1 uM vs 12 uM, respectively).
PC-62686	ML309 IDH1 R132H inhibitor	ML309 is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM, displays >380-fold selectivity over wt IDH1.

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