BRD2879 |CAS:1304750-47-7 Probechem Biochemicals

Chemical Structure : BRD2879

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BRD2879 (BRD-2879;BRD 2879)

货号: PC-35209Not For Human Use, Lab Use Only.

BRD2879 (BRD-2879) is a potent, selective inhibitor of IDH1-R132H mutant with IC50 of 50 nM, inhibits cell-based production of R-2HG with EC50 of 0.3 uM.

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生物&药学活性

BRD2879 (BRD-2879) is a potent, selective inhibitor of IDH1-R132H mutant with IC50 of 50 nM, inhibits cell-based production of R-2HG with EC50 of 0.3 uM.
BRD2879 shows weak inhibition against IDH1-R132C (IC50=2.5 uM), and no activity against IDH1-WT and IDH2-R140Q (IC50>20 uM).
BRD2879 displays competitive patterns with both the α-KG substrate and the Mg2+ cofactor.

物理化学性质&存储条件

分子量	571.708
分子式	C30H38FN3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-cyclohexyl-1-(((4R,5R)-8-((3-fluorophenyl)ethynyl)-2-((S)-1-hydroxypropan-2-yl)-4-methyl-1,1-dioxido-2,3,4,5-tetrahydrobenzo[b][1,4,5]oxathiazocin-5-yl)methyl)-1-methylurea

参考文献

1. Law JM, et al. ACS Med Chem Lett. 2016 Aug 18;7(10):944-949.

BRD2879 (BRD-2879;BRD 2879)

生物&药学活性

物理化学性质&存储条件

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BRD2879 (BRD-2879;BRD 2879)

生物&药学活性

物理化学性质&存储条件

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