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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Isocitrate Dehydrogenase (IDH)-SYC-435
SYC-435

Chemical Structure : SYC-435

CAS No.: 50405-58-8

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SYC-435 (SYC435, TC-E 5008)

货号: PC-35207Not For Human Use, Lab Use Only.

SYC-435 (SYC435) is a potent inhibitor of mutant IDH1, binds at the isocitrate pocket of mutated IDH1 with Ki values of 190 nM against IDH1 R132H and 120 nM against IDH1 R132C.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SYC-435 (TC-E 5008) is a potent inhibitor of mutant IDH1, binds at the isocitrate pocket of mutated IDH1 with Ki values of 190 nM against IDH1 R132H and 120 nM against IDH1 R132C.
    SYC-435 is cell active and capable of significantly reducing D-2-HG production in an HT1080 fibrosarcoma cell line expressing IDH1 R132C (IC50=2.4 uM).

    物理化学性质&存储条件

    分子量 215.252
    分子式 C13H13NO2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one

    参考文献

    1. Liu Z, et al. J Med Chem. 2014 Oct 23;57(20):8307-18.

    2. Ma T, et al. J Med Chem. 2018 Jun 18. doi: 10.1021/acs.jmedchem.8b00159.

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