Isocitrate Dehydrogenase (IDH) (inhibitors, antagonists, agonists)-ProbeChem.com

Request The Product List ofIsocitrate Dehydrogenase (IDH) Isocitrate Dehydrogenase (IDH)

Cat. No.	Product Name	Information
PC-60534	Vorasidenib mutant IDH1/2 inhibitor	Vorasidenib (AG-881) is a potent, oral, brain-penetrant dual inhibitor of mIDH1 and mIDH2 with IC50 of 6 nM and 12 nM for IDH1-R132H and IDH2-R140Q, respectively.
PC-60292	BAY-1436032 mutant IDH1 inhibitor	BAY-1436032 (BAY1436032) is a potent, selective, orally available inhibitor of pan-mutant IDH1 with IC50 of 15 nM for both IDH1 R132H and R132C, respectively.
PC-60164	IDH305 mutant IDH1 inhibitor	IDH 305 (IDH305) is a potent, selective, brain penetrant mutant IDH1 inhibitor with IC50 of 18 and 28 nM for IDH1 R132H and R132C.
PC-70088	GSK321 mutant IDH1 inhibitor	GSK321 is a highly potent, selective inhibitor of mutant IDH1 with IC50s of 4.6/3.8/2.9 nM for R132H/R132C/R132G respectively.
PC-45645	GSK864 IDH1 inhibitor	GSK864 is a compound structurally related to GSK321 with improved in vivo pharmacokinetic properties, inhibits IDH1 mutants R132C, R132H, and R132G with IC50 values of 8.8, 15.2 and 16.6 nM, respectively.
PC-45529	Enasidenib mutant IDH2 inhibitor	Enasidenib (AG-221, CC-90007) is an orally available, selective, potent inhibitor of mutant IDH2 with IC50s of 100-400 nM for IDH2R140Q homodimer, IDH2R172K homodimer and IDH2WT/R140Q, IDH2WT/R172K.
PC-45413	AGI-5198 mutant IDH1 inhibitor	AGI-5198 (IDH-C35) is a potent, selective mutant IDH1 inhibitor with IC50 of 70 nM and 160 nM for R132H-IDH1 and R132C-IDH1, respectively.
PC-44670	AGI-6780 IDH2 R140Q inhibitor	AGI-6780 is a potent and selective mutant IDH2 R140Q inhibitor with IC50 of 23 nM.
PC-45550	Ivosidenib mutant IDH1 inhibitor	Ivosidenib (AG-120) is a potent, mutant-selective inhibitor of IDH1 (isocitrate dehydrogenase type 1) with IC50 of 12 nM for mouse IDH1 R132H.
PC-20532	IDH2 R140Q inhibitor CP-17 IDH2 R140Q inhibitor	IDH2 R140Q inhibitor CP-17 is a potent, selective inhibitor of IDH2 R140Q mutation with IC50 of 40.75 nM, 50-fold selectivity over wild-type IDH1/2.
PC-43052	Mutant IDH1-IN-1	Mutant IDH1-IN-1 is a potent, mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.
PC-62685	ML309 hydrochloride	ML 309 is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM.

PREV 12NEXT