Enasidenib |CAS:1446502-11-9 Probechem Biochemicals

Chemical Structure : Enasidenib

CAS No.: 1446502-11-9

加入收藏

Enasidenib (AG-221, CC-90007, AG221)

货号: PC-45529Not For Human Use, Lab Use Only.

Enasidenib (AG-221, CC-90007) is an orally available, selective, potent inhibitor of mutant IDH2 with IC50s of 100-400 nM for IDH2R140Q homodimer, IDH2R172K homodimer and IDH2WT/R140Q, IDH2WT/R172K.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg	￥3980	In stock
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Enasidenib (AG-221, CC-90007) is an orally available, selective, potent inhibitor of mutant IDH2 with IC50s of 100-400 nM for IDH2R140Q homodimer, IDH2R172K homodimer and IDH2WT/R140Q, IDH2WT/R172K.
Enasidenib (AG-221, CC-90007) is less potent for IDH2WT homodimer and IDH1WT homodimer.
Enasidenib (AG-221, CC-90007) suppresses 2HG production and induces cellular differentiation in primary human IDH2 mutation-positive AML cells ex vivo and in xenograft mouse models.

物理化学性质&存储条件

分子量	473.375
分子式	C19H17F6N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Propanol, 2-methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-

参考文献

1. Yen K, et al. Cancer Discov. 2017 May;7(5):478-493.

2. Kats LM, et al. Leukemia. 2017 Apr 11. doi: 10.1038/leu.2017.84.

3. Shih AH, et al. Cancer Discov. 2017 May;7(5):494-505.

Enasidenib (AG-221, CC-90007, AG221)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Enasidenib (AG-221, CC-90007, AG221)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.