BAY-1436032 | IDH1 inhibitor | ProbeChem Biochemicals

Chemical Structure : BAY-1436032

CAS No.: 1803274-65-8

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BAY-1436032 (BAY1436032, BAY 1436032)

货号: PC-60292Not For Human Use, Lab Use Only.

BAY-1436032 (BAY1436032) is a potent, selective, orally available inhibitor of pan-mutant IDH1 with IC50 of 15 nM for both IDH1 R132H and R132C, respectively.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

BAY-1436032 (BAY1436032) is a potent, selective, orally available inhibitor of pan-mutant IDH1 with IC50 of 15 nM for both IDH1 R132H and R132C, respectively.
BAY-1436032 shows no effect on wild-type IDH1; strongly reduces 2-HG levels in cells carrying IDH1-R132H, -R132C, -R132G, -R132S and -R132L mutations.
BAY-1436032 significantly prolongs survival of mice intracerebrally transplanted with human astrocytoma carrying the IDH1R132H mutation.

物理化学性质&存储条件

分子量	489.54
分子式	C26H30F3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-((4-(trifluoromethoxy)phenyl)amino)-1-((1R,5R)-3,3,5-trimethylcyclohexyl)-1H-benzo[d]imidazol-5-yl)propanoic acid

参考文献

1. Pusch S, et al. Acta Neuropathol. 2017 Apr;133(4):629-644.

2. Chaturvedi A, et al. Leukemia. 2017 Oct;31(10):2020-2028.

3. Gokul S, et al. CNS Neurol Disord Drug Targets. 2017;16(6):636-637.

BAY-1436032 (BAY1436032, BAY 1436032)

生物&药学活性

物理化学性质&存储条件

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BAY-1436032 (BAY1436032, BAY 1436032)

生物&药学活性

物理化学性质&存储条件

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