ML309 | IDH1 R132H inhibitor | Probechem Biochemicals

Chemical Structure : ML309

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ML309 (ML 309, ML-309)

货号: PC-62686Not For Human Use, Lab Use Only.

ML309 is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM, displays >380-fold selectivity over wt IDH1.

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生物&药学活性

ML309 is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM, displays >380-fold selectivity over wt IDH1.
ML309 reduces cell-based production of 2-HG in a U87MG mutant glioblastoma cell line (IC50=509 nM) and show no cytotoxicity.
ML309 has good in vitro ADME and in vivo PK profile.

物理化学性质&存储条件

分子量	484.575
分子式	C29H29FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(1H-benzo[d]imidazol-1-yl)-N-(3-fluorophenyl)acetamido)-N-cyclopentyl-2-(o-tolyl)acetamide

参考文献

1. Merk A, et al. Cell. 2016 Jun 16;165(7):1698-707.

2. Davis M, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

3. Davis MI, et al. J Biol Chem. 2014 May 16;289(20):13717-25.

ML309 (ML 309, ML-309)

生物&药学活性

物理化学性质&存储条件

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ML309 (ML 309, ML-309)

生物&药学活性

物理化学性质&存储条件

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