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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Isocitrate Dehydrogenase (IDH)-AGI-6780
AGI-6780

Chemical Structure : AGI-6780

CAS No.: 1432660-47-3

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AGI-6780 (AGI 6780;AGI6780)

货号: PC-44670Not For Human Use, Lab Use Only.

AGI-6780 is a potent and selective mutant IDH2 R140Q inhibitor with IC50 of 23 nM.

规格 价格 库存 数量
5 mg (Free Sample) ￥280 In stock
25 mg ￥1880 In stock
50 mg ￥2880 In stock
100 mg ￥4480 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AGI-6780 is a potent and selective mutant IDH2 R140Q inhibitor with IC50 of 23 nM.
AGI-6780 shows excellent selectivity against other dehydrogenases.
AGI-6780 induces differentiation of TF-1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro.

物理化学性质&存储条件

分子量 481.5111
分子式 C21H18F3N3O3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 29 mg/mL
Chemical Name/SMILES

Benzenesulfonamide, N-cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-

参考文献

1. Wang F, et al. Science. 2013 May 3;340(6132):622-6.

2. Kernytsky A, et al. Blood. 2015 Jan 8;125(2):296-303.

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