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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Isocitrate Dehydrogenase (IDH)-Mutant IDH1-IN-1
Mutant IDH1-IN-1

Chemical Structure : Mutant IDH1-IN-1

CAS No.: 1355326-21-4

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Mutant IDH1-IN-1

货号: PC-43052Not For Human Use, Lab Use Only.

Mutant IDH1-IN-1 is a potent, mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Mutant IDH1-IN-1 is a potent, mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively; inhibits 2HG production in R132H IDH1-expressing HEK-293 cells with IC50 of 81.5 nM.

物理化学性质&存储条件

分子量 498.5912
分子式 C30H31FN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 45 mg/mL
Chemical Name/SMILES

1H-Benzimidazole-1-acetamide, N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-

参考文献

1. Deng G, et al. J Biol Chem. 2015 Jan 9;290(2):762-74.

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