HMS-101 | mutant IDH1 inhibitor | Probechem Biochemicals

Chemical Structure : HMS-101

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HMS-101 (HMS101)

货号: PC-35141Not For Human Use, Lab Use Only.

HMS-101 (HMS101) is a potent, selective mutant IDH1 inhibitor, the IC50 is significantly lower in mouse bone marrow cells transduced with IDH1mut compared with IDH1wt (1 uM vs 12 uM, respectively).

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生物&药学活性

HMS-101 (HMS101) is a potent, selective mutant IDH1 inhibitor, the IC50 is significantly lower in mouse bone marrow cells transduced with IDH1mut compared with IDH1wt (1 uM vs 12 uM, respectively).
HMS-101 binds to the isocitrate-binding pocket of mutant IDH1, significantly reduces intracellular R-2HG levels in vitro HoxA9+IDH1mut cells at 10 uM.
HMS-101 induces apoptosis in IDH1mut cells, markedly reduces phospho-ERK1/2 and the ratio of phospho-ERK/total-ERK, inhibits human AML cell growth.

物理化学性质&存储条件

分子量	305.441
分子式	C18H28FN3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[2-[3-(4-fluorophenyl)pyrrolidin-1-yl]ethyl]-1,4-dimethylpiperazine

参考文献

1. Chaturvedi A, et al. Blood. 2013 Oct 17;122(16):2877-87.

HMS-101 (HMS101)

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物理化学性质&存储条件

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HMS-101 (HMS101)

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物理化学性质&存储条件

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