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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Isocitrate Dehydrogenase (IDH)-mutant IDH1 inhibitor VVS
mutant IDH1 inhibitor VVS

Chemical Structure : mutant IDH1 inhibitor VVS

CAS No.: 1648909-73-2

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mutant IDH1 inhibitor VVS

货号: PC-35208Not For Human Use, Lab Use Only.

mutant IDH1 inhibitor VVS is a potent, selective c with nanomolar potency against both IDH1 R132H and IDH1 R132C, efficiently suppresses the cell-based production of D-2-HG in an HEK293 mutant embryonic kidney cell line.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    mutant IDH1 inhibitor VVS is a potent, selective mutant IDH1 inhibitor with nanomolar potency against both IDH1 R132H and IDH1 R132C, efficiently suppresses the cell-based production of D-2-HG in an HEK293 mutant embryonic kidney cell line.

    物理化学性质&存储条件

    分子量 366.509
    分子式 C22H30N4O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2,6-bis((1H-imidazol-1-yl)methyl)-4-(2,4,4-trimethylpentan-2-yl)phenol

    参考文献

    1. Deng G, et al. J Biol Chem. 2015 Jan 9;290(2):762-74.

    2. Ma T, et al. J Med Chem. 2018 Jun 18. doi: 10.1021/acs.jmedchem.8b00159.

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