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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Isocitrate Dehydrogenase (IDH)-Olutasidenib
Olutasidenib

Chemical Structure : Olutasidenib

CAS No.: 1887014-12-1

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Olutasidenib (FT-2102, FT2102)

货号: PC-35975Not For Human Use, Lab Use Only.

Olutasidenib (FT-2102) is a potent, orally bioavailable, brain penetrant, and selective mIDH1 inhibitor with IC50 of 21.2 nM and 114 nM for IDH1 mutant R132H and R132C, respectively.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3280 In stock
50 mg ￥5280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Olutasidenib (FT-2102) is a potent, orally bioavailable, brain penetrant, and selective mIDH1 inhibitor with IC50 of 21.2 nM and 114 nM for IDH1 mutant R132H and R132C, respectively.
FT-2102 has excellent ADME/PK properties and reduces 2-hydroxyglutarate levels in an mIDH1 xenograft tumor model.

物理化学性质&存储条件

分子量 354.794
分子式 C18H15ClN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-[[(1S)-1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino]-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile

参考文献

1. Caravella JA, et al. J Med Chem. 2020 Feb 27;63(4):1612-1623.
2. Rizzo A, et al. Cancer Treat Res Commun. 2021;27:100356.

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