MRK-A |CAS:1934301-68-4 Probechem Biochemicals

Chemical Structure : MRK-A

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MRK-A (mutant IDH1 inhibitor)

货号: PC-35142Not For Human Use, Lab Use Only.

MRK-A is a potent, highly selective, brain penetrant inhibitor of mutant IDH1 with IC50 of 5 nM, displays a 10,000-fold mutant to wildtype selectivity ratio.

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生物&药学活性

MRK-A is a potent, highly selective, brain penetrant inhibitor of mutant IDH1 with IC50 of 5 nM, displays a 10,000-fold mutant to wildtype selectivity ratio.
MRK-A decreases ntracellular 2-HG levels both in vitro and in vivo, inhibits 2-HG production in both BT142 and GB10 intracranial xenografts, as well as tumor growth.

物理化学性质&存储条件

分子量	454.574
分子式	C28H30N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(8-morpholino-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)methanone

参考文献

1. Kopinja J, et al. Sci Rep. 2017 Oct 23;7(1):13853.

MRK-A (mutant IDH1 inhibitor)

生物&药学活性

物理化学性质&存储条件

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MRK-A (mutant IDH1 inhibitor)

生物&药学活性

物理化学性质&存储条件

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