Interleukin Receptor (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-25547	4L2-P13D IL-11 antagonist	4L2-P13D is a potent, high-affinity macrocyclic peptide antagonist of interleukin-11 (IL-11) with binding KD of 11 nM and IC50 of 2.8 uM, shows significant renoprotective effects and antirenal fibrosis both in vitro and in vivo.
PC-25197	SMI-10B13 Oncostatin M inhibitor	SMI-10B13 is a first-in-class, small molecule inhibitor of Oncostatin M (OSM) with Kd of 6.6 uM, strongly inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines with IC50 of 136 and 164 nM, respectively.
PC-25141	IA-0130 gp130 inhibitor	IA-0130 a specific glycoprotein 130 (gp130, IL-6Rβ) inhibitor with SPR KD of 2.8 uM, interfers with the interaction between IL-6 and gp130, inhibits IL-6/gp130/STAT3 pathway activity.
PC-23454	IRI-1 IL-1R1/IL-1β inhibitor	IRI-1 is a specific interleukin-1 receptor I (IL-1R1)/interleukin 1β (IL-1β) interaction inhibitor with IC50 of 5.15 uM.
PC-21192	hIL-1β antagonist Compound (S)-2 hIL-1β antagonist	Compound (S)-2 is a specific antagonist of the hIL-1β /IL-1R1 (human interleukin-1β/IL-1R1) interaction with IC50 of 4.0 uM in TR-FRET assays, binds hIL-1β with SPR Kd of 1.1 uM.

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