| Cat. No. |
Product Name |
Information |
| PC-49391 |
Rytvela
IL-1RI inhibitor
|
Rytvela (Peptide 101.10, d-(RYTVELA)) is a potent, selective, allosteric negative modulator (antagonist) of IL-1 receptor I (IL-1RI), inhibits dose-dependently IL-1-induced PGE2 formation (IC50= 0.5 nM) and IL-1-induced human thymocyte (TF-1 cell) proliferation (IC50=2 nM). |
| PC-47087 |
IL-17A PPIm 23
IL-17A modulator
|
IL-17A PPIm 23 is a potent, orally bioavailable, small-molecule protein-protein interaction modulator (PPIm) of IL-17A, shows potential treatment of psoriasis and other inflammatory diseases. |
| PC-72919 |
A-552
L-36γ antagonist
|
A-552 (A552) is a potent, small molecule antagonist of human IL-36γ, exhibits Ki of 31/54 nM in IL-36γ evoked CXCL1 release in human/mouse cellular assays. |
| PC-72901 |
LP0200
IL17 modulator
|
LP0200 (IL-17 modulator 1 disodium, LP-0200) is a small-molecule modulator of IL-17 under development for psoriasis. |
| PC-72481 |
Nico-52
IL-4 inhibitor
|
Nico-52 (IL-4 inhibitor 52) is a specific small-molecule Interleukin-4 (IL-4) inhibitor with EC50 of 1.81 uM and SPR KD of 1.8 uM, disrupts type II IL-4 signaling in cells. |
| PC-35897 |
LMT-28
IL-6 inhibitor
|
LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6–induced luciferase activity), selectively inhibits IL-6–induced phosphorylation of STAT3, JAK2, and gp130. |
| PC-63195 |
RCGD423
gp130 modulator
|
RCGD423 (RCGD-423) is a small molecule gp130 modulator that prevents articular cartilage degeneration and promotes repair both in vitro and in vivo. |
| PC-62479 |
SP4206
IL-2α receptor inhibitor
|
SP4206 is a high-affinity (Kd=70 nM) small molecule that blocks the binding of the IL-2α receptor (IL-2Rα) to IL-2. |
| PC-45128 |
Suplatast tosilate
Th2 cytokine inhibitor
|
Suplatast tosilate (IPD-1151T) is a Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production. |
| PC-45769 |
YM-90709
IL-5 receptor inhibitor
|
YM-90709 (YM90709) is a potent IL-5 receptor antagonist that inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells with IC50 of 1.0 and 0.57 uM, respectively. |
| PC-26677 |
Anakinra
IL-1R antagonist
|
Anakinra (AMG719, AMG-719, Raleukin) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. |
| PC-26288 |
KYH1943
IL-33 antagonist
|
KYH1943 is a specific small-molecule inhibitor targeting IL-33/ST2 signaling, suppresses IL-33-induced Treg activation and proliferation. |
