Rytvela (Peptide 101.10, d-(RYTVELA))

Chemical Structure : Rytvela

加入收藏

货号: PC-49391Not For Human Use, Lab Use Only.

Rytvela (Peptide 101.10, d-(RYTVELA)) is a potent, selective, allosteric negative modulator (antagonist) of IL-1 receptor I (IL-1RI), inhibits dose-dependently IL-1-induced PGE2 formation (IC50= 0.5 nM) and IL-1-induced human thymocyte (TF-1 cell) proliferation (IC50=2 nM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Rytvela (Peptide 101.10, d-(RYTVELA)) is a potent, selective, allosteric negative modulator (antagonist) of IL-1 receptor I (IL-1RI), inhibits dose-dependently IL-1-induced PGE2 formation (IC50= 0.5 nM) and IL-1-induced human thymocyte (TF-1 cell) proliferation (IC50=2 nM).
[125I]101.10 binds specifically in a saturable manner with an affinity constant (KD) of 5 nM to thymocytes containing IL-1RI.
Rytvela (Peptide 101.10) diminished maximum TF-1 proliferation induced by IL-1 with an estimated pA2 value of 5 nM.
Rytvela (Peptide 101.10) is selective for IL-1, and inactive agqainst homologous cytokine of the IL-1 family IL-18.
Rytvela (Peptide 101.10) demonstrated robust in vivo effects in models of hyperthermia and inflammatory bowel disease as well as topically in contact dermatitis, superior to corticosteroids and IL-1ra; Rytvela (Peptide 101.10) did not bind to IL-1RI deficient cells and was ineffective in vivo in IL-1RI knockout mice.

物理化学性质&存储条件

分子量	850.972
分子式	C38H62N10O12
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	D-Arginyl-D-tyrosyl-D-threonyl-D-valyl-D-α-glutamyl-D-leucyl-D-alanine

参考文献

1. Quiniou C, et al. J Immunol. 2008 May 15;180(10):6977-87.