SP4206 | IL-2α receptor inhibitor | Probechem Biochemicals

Chemical Structure : SP4206

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SP4206 (SP-4206)

货号: PC-62479Not For Human Use, Lab Use Only.

SP4206 is a high-affinity (Kd=70 nM) small molecule that blocks the binding of the IL-2α receptor (IL-2Rα) to IL-2.

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生物&药学活性

SP4206 is a high-affinity (Kd=70 nM) small molecule that blocks the binding of the IL-2α receptor (IL-2Rα) to IL-2.
SP4206 targets virtually the same critical "hot-spot" residues on IL-2 that drive binding of IL-2Rα.

物理化学性质&存储条件

分子量	662.57
分子式	C30H37Cl2N7O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[[2,3-dichloro-4-[5-[1-[2-[[(2R)-2-(diaminomethylideneamino)-4-methylpentanoyl]amino]acetyl]piperidin-4-yl]-1-methylpyrazol-3-yl]phenoxy]methyl]furan-2-carboxylic acid

参考文献

1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.

2. Thanos CD, et al. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15422-7.

SP4206 (SP-4206)

生物&药学活性

物理化学性质&存储条件

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SP4206 (SP-4206)

生物&药学活性

物理化学性质&存储条件

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