LMT-28 | IL-6 inhibitor | Probechem Biochemicals

Chemical Structure : LMT-28

CAS No.: 1239600-18-0

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LMT-28 (LMT28)

货号: PC-35897Not For Human Use, Lab Use Only.

LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6–induced luciferase activity), selectively inhibits IL-6–induced phosphorylation of STAT3, JAK2, and gp130.

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10 mg	￥1380	In stock
25 mg	￥2480	In stock
50 mg	￥4280	In stock
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生物&药学活性

LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6-induced luciferase activity), selectively inhibits IL-6-induced phosphorylation of STAT3, JAK2, and gp130.
LMT-28 does not affect LIF-induced STAT3 activation and not inhibit IL-11 stimulation on HepG2 cells.
LMT-28 binds directly and specifically to gp130, and thereby inhibits the interaction of gp130 with the IL-6/IL-6Rα complex.
LMT-28 inhibits IL-6–induced proliferation of the human erythroleukemic cell line TF-1 with IC50 of 7.5 uM.
LMT-28 inhibits IL-6–induced TNF-α production, ameliorates the progression of pancreatitis in mice.

物理化学性质&存储条件

分子量	311.422
分子式	C17H29NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-((2S,3S)-3-hydroxy-2-methyl-4-methylenenonanoyl)-4-isopropyloxazolidin-2-one

参考文献

1. Hong SS, et al. J Immunol. 2015 Jul 1;195(1):237-45.

2. Armstead WM, et al. Transl Stroke Res. 2018 Feb 23. doi: 10.1007/s12975-018-0617-z.

LMT-28 (LMT28)

生物&药学活性

物理化学性质&存储条件

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LMT-28 (LMT28)

生物&药学活性

物理化学性质&存储条件

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