YM-90709 | IL-5 receptor inhibitor | Probechem Biochemicals

Chemical Structure : YM-90709

CAS No.: 163769-88-8

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YM-90709 (YM 90709, YM90709)

货号: PC-45769Not For Human Use, Lab Use Only.

YM-90709 (YM90709) is a potent IL-5 receptor antagonist that inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells with IC50 of 1.0 and 0.57 uM, respectively.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2280	In stock
100 mg	￥3680	In stock
250 mg		Get quote

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生物&药学活性

YM-90709 (YM90709) is a potent IL-5 receptor antagonist that inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells with IC50 of 1.0 and 0.57 uM, respectively.
YM-90709 inhibits IL-5-prolonged eosinophil survival with IC50 of 0.45 uM and does not affect the GM-CSF-prolonged eosinophil survival.
YM-90709 inhibits antigen-induced infiltration of eosinophils and lymphocytes into the bronchoalveolar lavage fluid (BALF) in BN rats (EC50=0.32 mg/kg and 0.12 mg/kg, respectively).

物理化学性质&存储条件

分子量	359.4211
分子式	C22H21N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benz[7,8]indolizino[2,3-b]quinoxaline, 5,6-dihydro-2,3-dimethoxy-6,6-dimethyl-

参考文献

1. Morokata T, et al. Int Immunopharmacol. 2002 Nov;2(12):1693-702.

2. Morokata T, et al. Int Immunopharmacol. 2004 Jul;4(7):873-83.

3. Morokata T, et al. Immunol Lett. 2005 Apr 15;98(1):161-5.

YM-90709 (YM 90709, YM90709)

生物&药学活性

物理化学性质&存储条件

参考文献

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YM-90709 (YM 90709, YM90709)

生物&药学活性

物理化学性质&存储条件

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