Interleukin Receptor (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-26149	IRA10L IL-36R inhibitor	IRA10L is a specific small molecule inhibitor of IL-36 receptor (IL-36R), inhibits IL-36-induced hCXCL1 secretion in HT29 cells with IC50 of 4.72 µM for IL-36γ, 5.81 µM for IL-36α, 14.55 µM for IL-36β, and 6.49 µM for the IL-36α/β/γ cocktail.
PC-25755	JNJ627 IL-17A inhibitor	JNJ627 (JNJ-627) is a small-molecule allosteric inhibitor of the IL-17A homodimer, inhibits IL-17A binding to IL-17RA with IC50 of 16 nM in TR-FRET assays.
PC-25547	4L2-P13D IL-11 antagonist	4L2-P13D is a potent, high-affinity macrocyclic peptide antagonist of interleukin-11 (IL-11) with binding KD of 11 nM and IC50 of 2.8 uM, shows significant renoprotective effects and antirenal fibrosis both in vitro and in vivo.
PC-25197	SMI-10B13 Oncostatin M inhibitor	SMI-10B13 is a first-in-class, small molecule inhibitor of Oncostatin M (OSM) with Kd of 6.6 uM, strongly inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines with IC50 of 136 and 164 nM, respectively.
PC-21192	hIL-1β antagonist Compound (S)-2 hIL-1β antagonist	Compound (S)-2 is a specific antagonist of the hIL-1β /IL-1R1 (human interleukin-1β/IL-1R1) interaction with IC50 of 4.0 uM in TR-FRET assays, binds hIL-1β with SPR Kd of 1.1 uM.

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