hIL-1β antagonist Compound (S)-2 | hIL-1β antagonist

Chemical Structure : hIL-1β antagonist Compound (S)-2

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hIL-1β antagonist Compound (S)-2 (Compound (S)-2)

货号: PC-21192Not For Human Use, Lab Use Only.

Compound (S)-2 is a specific antagonist of the hIL-1β /IL-1R1 (human interleukin-1β/IL-1R1) interaction with IC50 of 4.0 uM in TR-FRET assays, binds hIL-1β with SPR Kd of 1.1 uM.

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生物&药学活性

Compound (S)-2 is a specific antagonist of the hIL-1β /IL-1R1 (human interleukin-1β/IL-1R1) interaction with IC50 of 4.0 uM in TR-FRET assays, binds hIL-1β with SPR Kd of 1.1 uM.
Compound (S)-2 efficiently inhibits reporter activity induced by hIL-1β in a reporter gene assay in HEK293 cells (IC50=5.3 uM), but not hIL-1α.
Compound (S)-2 also shows no inhibitory activity against IL-36γ using a NanoBiT reporter system.
Compound (S)-2 blocks IL-1R-mediated signaling in cells, block IL-6 release with an IC50 in the single digit micromolar rang (IC50=7.9 uM).

物理化学性质&存储条件

分子量	469.45
分子式	C26H19N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4'-hydroxy-3'-(6-methyl-2-oxo-3-(1H-pyrazol-4-yl)indolin-3-yl)-[1,1'-biphenyl]-2,4-dicarboxylic acid

参考文献

1. Ulrich Hommel, et al. Nat Commun. 2023 Sep 7;14(1):5497.

hIL-1β antagonist Compound (S)-2 (Compound (S)-2)

生物&药学活性

物理化学性质&存储条件

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hIL-1β antagonist Compound (S)-2 (Compound (S)-2)

生物&药学活性

物理化学性质&存储条件

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