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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Interleukin Receptor-4L2-P13D
4L2-P13D

Chemical Structure : 4L2-P13D

CAS No.:

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4L2-P13D

货号: PC-25547Not For Human Use, Lab Use Only.

4L2-P13D is a potent, high-affinity macrocyclic peptide antagonist of interleukin-11 (IL-11) with binding KD of 11 nM and IC50 of 2.8 uM, shows significant renoprotective effects and antirenal fibrosis both in vitro and in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

4L2-P13D is a potent, high-affinity macrocyclic peptide antagonist of interleukin-11 (IL-11) with binding KD of 11 nM and IC50 of 2.8 uM, shows significant renoprotective effects and antirenal fibrosis both in vitro and in vivo.

物理化学性质&存储条件

分子量 1859.13
分子式 C89H123N19O23S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

[H]N1[C@@H](CC2=CC=C(C=C2)O)C(N[C@H](C(N[C@]([H])(C(N[C@H](C(N[C@@H](CC3=CN=CN3)C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@@H](CC5=CC=C(O)C=C5)C(N[C@]([H])(C(N[C@@H](CC6=CC=CC=C6)C(N[C@]([H])(C(N[C@@H](C)C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CSCC1=O)C(NCC(N)=O)=O)=O)=O)CC(C)C)=O)=O)[C@H](CC)C)=O)=O)[C@@H](C)O)=O)=O)=O)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CC(C)C)=O

参考文献

1. ChunMei An, et al. J Med Chem. 2025 Sep 18. doi: 10.1021/acs.jmedchem.5c01432.

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