| Cat. No. |
Product Name |
Information |
| PC-49763 |
Picropodophyllotoxin
IGF1R inhibitor
|
Picropodophyllotoxin (AXL1717, PPT) is a selective orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor with IC50 of 1 nM, no activity against insulin receptor, FGFR, PDGFR or EGFR. |
| PC-49759 |
GTX-134
IGF-1R/IR inhibitor
|
GTx-134 (GTx 134) is a selective small-molecule inhibitor of IGF-1R and insulin receptor (IR) with biochemical IC50 of 97 nM and 187 nM, respectively. |
| PC-49233 |
BM001
GH/IGF1 inhibitor
|
BM001 (BM-001) is a small molecular inhibitor of the integral growth hormone/insulin‐like growth factor‐1 (GH/IGF1) axis, shows potent antiproliferative effect on cancer cells MDA-MM-231 and Colo-205 with IC50 of 20-30 nM. |
| PC-43330 |
GSK1838705A
IGF-IR/ALK inhibitor
|
GSK1838705A is a potent, specific inhibitor of IGF-IR and insulin receptor (IR) with IC50 of 2.0 and 1.6 nM, also is a potent inhibitor of ALK with IC50 of 0.5 nM. |
| PC-62993 |
BMS-695735
IGF-1R inhibitor
|
BMS-695735 is a potent, selective IGF-1R inhibitor with IC50 of 34 nM. |
| PC-61655 |
Chromeceptin
IGF2 inhibitor
|
Chromeceptin (94G6) is a cell-permeable benzochromene that selectively impairs the viability and growth of IGF2 (insulin-like growth factor 2)-overexpressing hepatocellular carcinoma cells, binds to MFP-2, stimulates the expression of IGFBP-1 and SOCS-3 through activation of STAT6. |
| PC-61142 |
AZD9362
IGF-1R inhibitor
|
AZD-9362 (AZD9362) is a potent, selective, orally bioavailable IGF-1R inhibitor with IC50 of 14 nM. |
| PC-61008 |
WP760
|
A bis-anthracycline and melanoma selective agent that demonstrates anti-melanoma activity at low nanomolar concentrations. |
| PC-60348 |
BI 885578
IGF1R/InsR inhibitor
|
BI 885578 (BI-885578, BI885578) is a potent,selective, ATP-competitive IGF1R/InsR tyrosine kinase inhibitor with Kd of 9 nM/12 nM, IC50 of 1 nM/1 nM, respectively. |
| PC-42488 |
AG1024
IGF-1R inhibitor
|
A specific IGF-1R inhibitor that inhibits IGF-1R autophosphorylation with IC50 of 7 uM. |
| PC-42487 |
NVP-ADW742
IGF-1R inhibitor
|
NVP-ADW742 is a selective IGF-1R kinase inhibitor that with IC50 of 0.17 uM in in cellular autophosphorylation assays. |
| PC-42436 |
Linsitinib
IGF1R/InsR inhibitor
|
Linsitinib (ASP-7487, OSI-906) is a potent, selective, orally active, dual IGF-1R/insulin receptor inhibitor with IC50 of 35/75 nM, respectively. |
