Linsitinib | IGF1R/InsR inhibitor | Probechem Biochemicals

Chemical Structure : Linsitinib

CAS No.: 867160-71-2

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Linsitinib (ASP-7487;ASP 7487;OSI-906;OSI906)

货号: PC-42436Not For Human Use, Lab Use Only.

Linsitinib (ASP-7487, OSI-906) is a potent, selective, orally active, dual IGF-1R/insulin receptor inhibitor with IC50 of 35/75 nM, respectively.

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2 mg (Free Sample)	￥280	In stock
10 mg	￥1380	In stock
25 mg	￥2280	In stock
50 mg	￥3780	In stock
100 mg		Get quote

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生物&药学活性

Linsitinib (ASP-7487, OSI-906) is a potent, selective, orally active, dual IGF-1R/insulin receptor inhibitor with IC50 of 35/75 nM, respectively.
Linsitinib (ASP-7487, OSI-906) potently and selectively inhibits autophosphorylation of both human IGF-1R and IR, displays in vitro antiproliferative effects in a variety of tumor cell lines.
Linsitinib (ASP-7487, OSI-906) shows robust in vivo anti-tumor efficacy in an IGF-1R-driven xenograft model.

物理化学性质&存储条件

分子量	421.4937
分子式	C26H23N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclobutanol, 3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-, cis-

参考文献

1. Mulvihill MJ, et al. Future Med Chem. 2009 Sep;1(6):1153-71.

2. Pitts TM, et al. Clin Cancer Res. 2010 Jun 15;16(12):3193-204.

3. Buck E, et al. Mol Cancer Ther. 2010 Oct;9(10):2652-64.

4. Kuhn DJ, et al. Blood. 2012 Oct 18;120(16):3260-70.

Linsitinib (ASP-7487;ASP 7487;OSI-906;OSI906)

生物&药学活性

物理化学性质&存储条件

参考文献

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Linsitinib (ASP-7487;ASP 7487;OSI-906;OSI906)

生物&药学活性

物理化学性质&存储条件

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