Chromeceptin (94G6)

Chemical Structure : Chromeceptin

CAS No.: 331859-86-0

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货号: PC-61655Not For Human Use, Lab Use Only.

Chromeceptin (94G6) is a cell-permeable benzochromene that selectively impairs the viability and growth of IGF2 (insulin-like growth factor 2)-overexpressing hepatocellular carcinoma cells, binds to MFP-2, stimulates the expression of IGFBP-1 and SOCS-3 through activation of STAT6.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Chromeceptin (94G6) is a cell-permeable benzochromene that selectively impairs the viability and growth of IGF2 (insulin-like growth factor 2)-overexpressing hepatocellular carcinoma cells, binds to MFP-2, stimulates the expression of IGFBP-1 and SOCS-3 through activation of STAT6.
Chromeceptin blocks insulin-induced adipogenesis in 3T3-L1 cells (100% blockage at <20 ng/uL) and selectively suppresses IGF2-dependent growth of HepG2 carcinoma cells (IC50=29 nM).
Chromeceptin is a potent IGF2 signaling inhibitor.

物理化学性质&存储条件

分子量	359.35
分子式	C19H16F3N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-4H-chromene-3-carbonitrile

参考文献

1. Choi Y, et al. Chem Biol. 2006 Mar;13(3):241-9.

2. Jung D, et al. Biochem J. 2012 Dec 15;448(3):409-16.