BM001 | GH/IGF1 inhibitor | Probechem Biochemicals

Chemical Structure : BM001

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BM001 (BM-001)

货号: PC-49233Not For Human Use, Lab Use Only.

BM001 (BM-001) is a small molecular inhibitor of the integral growth hormone/insulin‐like growth factor‐1 (GH/IGF1) axis, shows potent antiproliferative effect on cancer cells MDA-MM-231 and Colo-205 with IC50 of 20-30 nM.

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100 mg		Get quote

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生物&药学活性

BM001 (BM-001) is a small molecular inhibitor of the integral growth hormone/insulin‐like growth factor‐1 (GH/IGF1) axis, shows potent antiproliferative effect on cancer cells MDA-MM-231 and Colo-205 with IC50 of 20-30 nM.
BM001 (0.1-1 uM) effectively inhibits the synthesis of fos-GHRct in vitro translation experiments.
BM001 shows potential to inhibit GH-driven cancer growth and anti-cancer drug resistance.
BM001 (1-5 mg/kg) inhibited tumor growth on breast cancer growth in mice, reduced serum IGF1 levels with no effect on body weights.

物理化学性质&存储条件

分子量	334.346
分子式	C17H17F3N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-6-methyl-5-(2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)vinyl)pyrimidine-2,4-diamine

参考文献

1. Lieke M van der Velden, et al. Front Endocrinol (Lausanne). 2022 Jul 28;13:926210.

BM001 (BM-001)

生物&药学活性

物理化学性质&存储条件

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BM001 (BM-001)

生物&药学活性

物理化学性质&存储条件

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