BMS-695735 | IGF-1R inhibitor | Probechem Biochemicals

Chemical Structure : BMS-695735

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BMS-695735 (BMS 695735)

货号: PC-62993Not For Human Use, Lab Use Only.

BMS-695735 is a potent, selective IGF-1R inhibitor with IC50 of 34 nM.

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生物&药学活性

BMS-695735 is a potent, selective IGF-1R inhibitor with IC50 of 34 nM.
BMS-695735 also inhibits IR/FAK/Lck (IC50=72/165/14 nM), and no significant activity against PKCα, PKCδ, IKK, Akt, CDK2, CYP3A4, and PXR.
BMS-695735 exhibits improved ADME properties, a low risk for drug-drug interactions, and in vivo efficacy in multiple xenograft models; orally efficacious.

物理化学性质&存储条件

分子量	512.03
分子式	C26H31ClFN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one

参考文献

1. Velaparthi U, et al. J Med Chem. 2008 Oct 9;51(19):5897-900.

BMS-695735 (BMS 695735)

生物&药学活性

物理化学性质&存储条件

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BMS-695735 (BMS 695735)

生物&药学活性

物理化学性质&存储条件

参考文献

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