AZD9362 | IGF-1R inhibitor | Probechem Biochemicals

Chemical Structure : AZD9362

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AZD9362 (AZD-9362, AZD 9362)

货号: PC-61142Not For Human Use, Lab Use Only.

AZD-9362 (AZD9362) is a potent, selective, orally bioavailable IGF-1R inhibitor with IC50 of 14 nM.

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生物&药学活性

AZD-9362 (AZD9362) is a potent, selective, orally bioavailable IGF-1R inhibitor with IC50 of 14 nM.
AZD-9362 weakly inhibits CDK1/2/7/8/9 with IC50 of 300-800 nM, displays good kinase selectivity in a panel of 60 kinases.
AZD-9362 inhibits the auto-phosphorylation of IGF-1R after IGF1 stimulation in mice fibroblasts with IC50 of 48 nM, inhibits IGF-driven growth of tumour allografts.

物理化学性质&存储条件

分子量	494.984
分子式	C24H27ClN8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R)-1-[4-(4-{[5-chloro-4-(pyrazolo[1,5-a]pyridin-3-yl)-2-pyrimidinyl]amino}-3,5-dimethyl-1H-pyrazol-1-yl)-1-piperidinyl]-2-hydroxy-1-propanone

参考文献

1. Degorce SL, et al. J Med Chem. 2016 May 26;59(10):4859-66.

2. Fox EM, et al. Breast Cancer Res. 2013;15(4):R55.

AZD9362 (AZD-9362, AZD 9362)

生物&药学活性

物理化学性质&存储条件

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AZD9362 (AZD-9362, AZD 9362)

生物&药学活性

物理化学性质&存储条件

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