NVP-ADW742 | IGF-1R inhibitor | Probechem Biochemicals

Chemical Structure : NVP-ADW742

CAS No.: 475488-23-4

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NVP-ADW742 (ADW742;GSK 552602A)

货号: PC-42487Not For Human Use, Lab Use Only.

NVP-ADW742 is a selective IGF-1R kinase inhibitor that with IC50 of 0.17 uM in in cellular autophosphorylation assays.

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5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥3180	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

NVP-ADW742 is a selective IGF-1R kinase inhibitor that with IC50 of 0.17 uM in in cellular autophosphorylation assays.
NVP-ADW742 has >16-fold more potent inhibitory effect against IGF-1R than InsR.
NVP-ADW742 has no activity for HER2, PDGFR, VEGFR-2, Bcr-Abl p210, and c-Kit.
NVP-ADW742 has in vitro activity against diverse tumor cell types (particularly multiple myeloma) and significant antitumor activity in an orthotopic xenograft MM model.

物理化学性质&存储条件

分子量	453.5786
分子式	C28H31N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-[3-(phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-

参考文献

1. Mitsiades CS, et al. Cancer Cell. 2004 Mar;5(3):221-30.

2. Warshamana-Greene GS, et al. Mol Cancer Ther. 2004 May;3(5):527-35.

3. Warshamana-Greene GS, et al. Clin Cancer Res. 2005 Feb 15;11(4):1563-71.

NVP-ADW742 (ADW742;GSK 552602A)

生物&药学活性

物理化学性质&存储条件

参考文献

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NVP-ADW742 (ADW742;GSK 552602A)

生物&药学活性

物理化学性质&存储条件

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