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首页-小分子抑制剂&激动剂-Tyrosine Kinase-IGF-1R-AG1024
AG1024

Chemical Structure : AG1024

CAS No.: 65678-07-1

AG1024 (AG-1024, Tyrphostin AG1024)

货号: PC-42488Not For Human Use, Lab Use Only.

A specific IGF-1R inhibitor that inhibits IGF-1R autophosphorylation with IC50 of 7 uM.

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1 mg (Free Sample) ¥280 In stock
10 mg ¥880 In stock
50 mg ¥1980 In stock
100 mg ¥3280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AG1024 (Tyrphostin AG1024) is a specific IGF-1R inhibitor that inhibits IGF-1R autophosphorylation with IC50 of 7 uM.
AG1024 weakly blocks IR autophosphorylation with IC50 of 57 uM.
AG1024 also inhibits the receptor tyrosine kinase activity towards exogenous substrates (TKA) with IC50 of 18 μuM and 80 uM, respectively.
AG1024 down-regulates expression of Bcr-Abl and P-Akt, and up-regulates DNA-PKcs expression in UT7-9 and Ba/F3-p210 cells.

物理化学性质&存储条件

分子量 305.1698
分子式 C14H13BrN2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Propanedinitrile, 2-[[3-bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-

参考文献

1. Párrizas M, et al. Endocrinology. 1997 Apr;138(4):1427-33.

2. Wen B, et al. Br J Cancer. 2001 Dec 14;85(12):2017-21.

3. von Willebrand M, et al. Cancer Res. 2003, 63(6), 1420-1429.

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