| Cat. No. |
Product Name |
Information |
| PC-43254 |
UC-112
IAP inhibitor
|
UC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM. |
| PC-43119 |
AZD5582
IAP inhibitor
|
AZD5582 is a dimeric Smac mimetic, potent IAP antagonist that binds potently to the BIR3 domains of cIAP1, cIAP2 and XIAP with IC50 of 15, 21and 15 nM, respectively. |
| PC-62352 |
PS1
IAP inhibitor
|
PS1 is a potent inhibitor of IAP family with IC50 of 36/96/33 nM for c-IAP1/c-IAP2/XIAP respectively.. |
| PC-62351 |
SM-1295
cIAP1/2 inhibitor
|
SM-1295 is a potent, selective cIAP1 and cIAP2 inhibitor with Ki of <10 nM, displays >900-fold for cIAP1 over XIAP. |
| PC-62350 |
CS3
cIAP1/2 inhibitor
|
CS3 is a potent, selective cIAP1 and cIAP2 inhibitor with IC50 of 16 nM and 85 nM respectively, shows no significant activity against XIAP (IC50>34 uM).. |
| PC-61034 |
T-3256336
IAP inhibitor
|
T-3256336 is a potent, selective, orally available IAP antagonist with IC50 of 1.3, 2.2 and 200 nM for cIAP-1, cIAP-2 and XIAP, respectively. |
| PC-70207 |
MV1
IAP inhibitor
|
MV1 is a small-molecule IAP antagonist that binds to select baculovirus IAP repeat (BIR) domains resulting in dramatic induction of auto-ubiquitination activity and rapid proteasomal degradation of c-IAPs. |
| PC-60254 |
AT-IAP
XIAP/cIAP1 inhibitor
|
A potent, orally bioavailable, dual XIAP/cIAP1 inhibitor with EC50 of 5.1/0.32 nM, respectively. |
| PC-45046 |
BV6
IAP inhibitor
|
BV6 is a small molecule, bivalent IAP antagonist that binds to the c-IAP1 and XIAP BIR2-BIR3 domains with Kd of 0.46 and 0.029 nM, respectively. |
| PC-42440 |
YM-155 hydrochloride
Survivin inhibitor
|
YM-155 hydrochloride is a potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM. |
| PC-45289 |
Embelin
XIAP inhibitor
|
Embelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties, specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50=4.1 uM). |
| PC-23123 |
IAP antagonist Compound A
IAP Antagonist
|
IAP antagonist Compound A is a highly potent, Smac-mimetic IAP antagonist with equivalent binding affinity to XIAP and cIAP1 in the picomolar range, induces rapid degradation of cIAP1, activates NF-κB signaling via inhibtion of cIAP1 and induces TNFα-dependent apoptosis. |
