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首页-小分子抑制剂&激动剂-Apoptosis-IAP-MV1
MV1

Chemical Structure : MV1

CAS No.: 1001600-54-9

MV1 (IAP antagonist MV1)

货号: PC-70207Not For Human Use, Lab Use Only.

MV1 is a small-molecule IAP antagonist that binds to select baculovirus IAP repeat (BIR) domains resulting in dramatic induction of auto-ubiquitination activity and rapid proteasomal degradation of c-IAPs.

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5 mg ¥2580 In stock
10 mg ¥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MV1 is a small-molecule IAP antagonist that binds to select baculovirus IAP repeat (BIR) domains resulting in dramatic induction of auto-ubiquitination activity and rapid proteasomal degradation of c-IAPs.
MV1 induces cell death that is dependent on TNF signaling and de novo protein biosynthesis.

物理化学性质&存储条件

分子量 576.738
分子式 C33H44N4O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl 2-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamido)-3,3-diphenylpropanoate

参考文献

1. Varfolomeev E, et al. Cell. 2007 Nov 16;131(4):669-81.

2. Shibata N, et al. J Med Chem. 2017 Jun 23. doi: 10.1021/acs.jmedchem.7b00168.

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