AZD5582 | IAP inhibitor | Probechem Biochemicals

Chemical Structure : AZD5582

CAS No.: 1258392-53-8

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AZD5582 (AZD-5582)

货号: PC-43119Not For Human Use, Lab Use Only.

AZD5582 is a dimeric Smac mimetic, potent IAP antagonist that binds potently to the BIR3 domains of cIAP1, cIAP2 and XIAP with IC50 of 15, 21and 15 nM, respectively.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

AZD5582 is a dimeric Smac mimetic, potent IAP antagonist that binds potently to the BIR3 domains of cIAP1, cIAP2 and XIAP with IC50 of 15, 21and 15 nM, respectively.
AZD5582 causes cIAP1 degradation and induces apoptosis in the MDA-MB-231 breast cancer cell line at subnanomolar concentrations in vitro.
AZD5582 induces cIAP1 degradation and caspase-3 cleavage within tumor cells and causes substantial tumor regressions in MDA-MB-231 xenograft-bearing mice.

物理化学性质&存储条件

分子量	1015.289
分子式	C58H78N8O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 66.25 mg/mL
Chemical Name/SMILES	L-Prolinamide, 3,3'-[2,4-hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-

参考文献

1. Hennessy EJ, et al. J Med Chem. 2013 Dec 27;56(24):9897-919.

2. Moon JH, et al. Oncotarget. 2015 Sep 29;6(29):26895-908.

3. Zhuang J, et al. Pharmacol Res Perspect. 2014 Dec;2(6):e00081.

AZD5582 (AZD-5582)

生物&药学活性

物理化学性质&存储条件

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AZD5582 (AZD-5582)

生物&药学活性

物理化学性质&存储条件

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