UC-112 |CAS:383392-66-3 Probechem Biochemicals

Chemical Structure : UC-112

CAS No.: 383392-66-3

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UC-112 (UC112)

货号: PC-43254Not For Human Use, Lab Use Only.

UC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
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100 mg		Get quote

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生物&药学活性

UC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM.
UC-112 also potently inhibits the growth of P-gp-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at 1 uM.
UC-112 strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo.

物理化学性质&存储条件

分子量	348.4382
分子式	C22H24N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-Quinolinol, 5-[(phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-

参考文献

1. Wang J, et al. J Pharmacol Exp Ther. 2014 May;349(2):319-29.

2. Xiao M, et al. PLoS One. 2015 Jun 12;10(6):e0129807.

UC-112 (UC112)

生物&药学活性

物理化学性质&存储条件

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UC-112 (UC112)

生物&药学活性

物理化学性质&存储条件

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