AT-IAP |CAS:1403898-55-4 Probechem Biochemicals

Chemical Structure : AT-IAP

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AT-IAP (AT IAP)

货号: PC-60254Not For Human Use, Lab Use Only.

A potent, orally bioavailable, dual XIAP/cIAP1 inhibitor with EC50 of 5.1/0.32 nM, respectively.

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生物&药学活性

AT-IAP is a potent, orally bioavailable, dual XIAP/cIAP1 inhibitor with EC50 of 5.1/0.32 nM, respectively.
AT-IAP exhibits MDA-MB-231 cell proliferation inhibition with IC50 of 4.4 nM.
AT-IAP decreases basal and TNF-α-induced cIAP-1 expression in CaP cells, switches TNF-α signaling from pro-survival to pro-apoptotic and increases radiation sensitivity of CaP cells in co-culture with THP-1 cells.
AT-IAP shows in vivo efficacy in Balb/c scid mice bearing MDA-MB-231 xenografts.

物理化学性质&存储条件

分子量	509.67
分子式	C29H40FN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(6-(4-fluorobenzyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethan-1-one

参考文献

1. Tamanini E, et al. J Med Chem. 2017 Jun 8;60(11):4611-4625.

2. Armstrong CW, et al. Oncotarget. 2016 Feb 16;7(7):7885-98.

AT-IAP (AT IAP)

生物&药学活性

物理化学性质&存储条件

参考文献

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AT-IAP (AT IAP)

生物&药学活性

物理化学性质&存储条件

参考文献

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