YM-155 hydrochloride |CAS:355406-09-6 Probechem Biochemicals

Chemical Structure : YM-155 hydrochloride

CAS No.: 355406-09-6

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YM-155 hydrochloride (YM155 hydrochloride;YM 155 hydrochloride)

货号: PC-42440Not For Human Use, Lab Use Only.

YM-155 hydrochloride is a potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM.

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25 mg	￥1880	In stock
50 mg	￥2980	In stock
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200 mg		Get quote
1 g		Get quote

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生物&药学活性

YM-155 hydrochloride is a potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM.
YM-155 does not significantly inhibit SV40 promoter activity (>30 uM).
YM-155 suppresses expression of survivin and induces apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nM, without effect on IAP- or Bcl-2-related proteins.
YM-155 induces massive tumor regression in PC-3 tumor mice model (3-10 mg/kg).

物理化学性质&存储条件

分子量	398.8429
分子式	C20H19ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-3-(2-methoxyethyl)-2-methyl-4,9-dioxo-1-(2-pyrazinylmethyl)-, chloride (1:1)

参考文献

1. Nakahara T, et al. Cancer Res. 2007 Sep 1;67(17):8014-21.

2. Iwasa T, et al. Clin Cancer Res. 2008 Oct 15;14(20):6496-504.

3. Satoh T, et al. Clin Cancer Res. 2009 Jun 1;15(11):3872-80.

4. Iwasa T, et al. Br J Cancer. 2010 Jun 29;103(1):36-42.

YM-155 hydrochloride (YM155 hydrochloride;YM 155 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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YM-155 hydrochloride (YM155 hydrochloride;YM 155 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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