T-3256336 |CAS:1266227-69-3 Probechem Biochemicals

Chemical Structure : T-3256336

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T-3256336 (T3256336;T 3256336)

货号: PC-61034Not For Human Use, Lab Use Only.

T-3256336 is a potent, selective, orally available IAP antagonist with IC50 of 1.3, 2.2 and 200 nM for cIAP-1, cIAP-2 and XIAP, respectively.

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生物&药学活性

T-3256336 is a potent, selective, orally available IAP antagonist with IC50 of 1.3, 2.2 and 200 nM for cIAP-1, cIAP-2 and XIAP, respectively.
T-3256336 dose dependently antagonizes XIAP and promotes the activities of caspase-3 with EC50 of 1.3 uM in cell-free assays.
T-3256336 induces the rapid proteasomal degradation of cIAP-1 and activates TNF-α-dependent extrinsic apoptosis signaling in cultured cells.
T-3256336 induces cIAP-1 degradation, TNF-α production and caspase activation in cancer xenograft models.

物理化学性质&存储条件

分子量	605.728
分子式	C31H45F2N5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyrrolo[1,2-a]pyrazine-3-carboxamide, 2-[(2S)-2-(4,4-difluorocyclohexyl)-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]acetyl]-N-[(4R)-3,4-dihydro-2H-1-benzopyran-4-yl]-7-ethoxyoctahydro-, (3S,7R,8aR)-

参考文献

1. Sumi H, et al. Mol Cancer Ther. 2013 Feb;12(2):230-40.

2. Hashimoto K, et al. J Med Chem. 2013 Feb 14;56(3):1228-46.

3. Sumi H, et al. Biochem Biophys Res Commun. 2016 Oct 14;479(2):179-185.

T-3256336 (T3256336;T 3256336)

生物&药学活性

物理化学性质&存储条件

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T-3256336 (T3256336;T 3256336)

生物&药学活性

物理化学性质&存储条件

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