Focal Adhesion Kinase (FAK) (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-62799	PF-4618433 Pyk2 inhibitor	PF-4618433 (PF4618433) is a highly potent, selective PYK2 inhibitor with IC50 of 637 nM, promotes osteogenesis of hMSC cultures.
PC-62798	Pyk2-IN-25a Pyk2 inhibitor	Pyk2-IN-25a is a highly potent Pyk2 (PTK2B) inhibitor with IC50 of 0.67 nM, dispalys 2-fold weakening potency for FAK (IC50=1.26 nM).
PC-61370	Conteltinib FAK inhibitor	CT-707 (Conteltinib) is a novel multikinase inhibitor targeting FAK (IC50=1.6 nM), ALK and Pyk2, exerts synergistic antitumor effects against hepatocellular carcinoma in vitro and in vivo.
PC-70128	OXA-11 FAK inhibitor	OXA-11 is a potent and selective inhibitor of FAK phosphorylation with biochemical IC50 of 1.2 pM (pFAK Y397), cellular IC50 of 1 nM.
PC-60275	BI-853520 PTK2/FAK inhibitor	Ifebemtinib (BI 853520, IN10018) is potent, highly selective and orally active inhibitor of PTK2/FAK with IC50 of 1 nM in cell-free assays.
PC-45578	TAS-301 FAK inhibitor	TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, inhibits PDGF-induced tyrosine phosphorylation of both FAK and paxillin.
PC-42177	GSK2256098 FAK inhibitor	GSK2256098 (GTPL-7939) is a potent, selective, reversible and ATP-competitive inhibitor of FAK kinase with Ki of 0.4 nM.
PC-42601	PF-562271 FAK/Pyk2 inhibitor	PF-562271 (VS-6062) is a potent, selective, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 14 nM, respectively.
PC-42600	PF-562271 besylate FAK/Pyk2 inhibitor	A potent, selective, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 14 nM, respectively.
PC-42602	PF-573228 FAK inhibitor	PF-573228 is a potent, selective, ATP-competitive FAK inhibitor with IC50 of 4 nM.
PC-22945	M64HCl FAK activator	M64HCl is a specific small molecule, water-soluble focal adhesion kinase (FAK) activator, interacts directly with the FAK kinase domain to activate FAK, induces epithelial sheet migration in vitro, and stimulates gut mucosal wound healing in vivo.
PC-22876	FAK inhibitor E2 FAK inhibitor	FAK inhibitor E2 is a potent selective FAK inhibitor with IC50 of 3.58 nM, inhibits FAK downstream signaling cascades (e.g., Src and AKT), induces cytotoxic autophagy and inhibits ovarian cancer metastasis and growth.

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