PF-573228 |CAS:869288-64-2 Probechem Biochemicals

Chemical Structure : PF-573228

CAS No.: 869288-64-2

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PF-573228 (PF573228;PF 573228)

货号: PC-42602Not For Human Use, Lab Use Only.

PF-573228 is a potent, selective, ATP-competitive FAK inhibitor with IC50 of 4 nM.

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5 mg (Free Sample)	￥180	In stock
10 mg	￥980	In stock
25 mg	￥1480	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

PF-573228 is a potent, selective, ATP-competitive FAK inhibitor with IC50 of 4 nM.
PF-573228 displays 250-fold selectivity over Pyk2, 50–250-fold over a panel of kinases (CDK1, CDK7, GSK3β).
PF-573228 inhibits FAK phosphorylation on Tyr397 in cultured cells (IC50=30-100 nM), inhibits both chemotactic and haptotactic migration.

物理化学性质&存储条件

分子量	491.4861
分子式	C22H20F3N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 51 mg/mL
Chemical Name/SMILES	2(1H)-Quinolinone, 3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-

参考文献

1. Slack-Davis JK, et al. J Biol Chem. 2007 May 18;282(20):14845-52.

2. Jones ML, et al. Biochem Biophys Res Commun. 2009 Nov 6;389(1):198-203.

3. Hiscox S, et al. Breast Cancer Res Treat. 2011 Feb;125(3):659-69.

PF-573228 (PF573228;PF 573228)

生物&药学活性

物理化学性质&存储条件

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PF-573228 (PF573228;PF 573228)

生物&药学活性

物理化学性质&存储条件

参考文献

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