PF-562271 besylate |CAS:939791-38-5 Probechem Biochemicals

Chemical Structure : PF-562271 besylate

CAS No.: 939791-38-5

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PF-562271 besylate (PF562271 besylate;PF 562271 besylate)

货号: PC-42600Not For Human Use, Lab Use Only.

A potent, selective, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 14 nM, respectively.

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5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2580	In stock
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100 mg		Get quote

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生物&药学活性

PF-562271 besylate is a potent, selective, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 14 nM, respectively.
PF-562271 displayes robust inhibition in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM.
PF-562271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion (EC50=93 ng/mL) after in tumor-bearing mice; orally bioavailable.

物理化学性质&存储条件

分子量	665.6639
分子式	C27H26F3N7O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: 21.4 mg/mL
Chemical Name/SMILES	Methanesulfonamide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl-, benzenesulfonate (1:1)

参考文献

1. Roberts WG, et al. Cancer Res. 2008 Mar 15;68(6):1935-44.

2. Stokes JB, et al. Mol Cancer Ther. 2011 Nov;10(11):2135-45.

3. Slack-Davis JK, et al. Mol Cancer Ther. 2009 Aug;8(8):2470-7.

PF-562271 besylate (PF562271 besylate;PF 562271 besylate)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-562271 besylate (PF562271 besylate;PF 562271 besylate)

生物&药学活性

物理化学性质&存储条件

参考文献

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