BI-853520 | FAK inhibitor | ProbeChem Biochemicals

Chemical Structure : BI-853520

CAS No.: 1227948-82-4

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BI-853520 (Ifebemtinib, BI 853520, IN10018)

货号: PC-60275Not For Human Use, Lab Use Only.

Ifebemtinib (BI 853520, IN10018) is potent, highly selective and orally active inhibitor of PTK2/FAK with IC50 of 1 nM in cell-free assays.

规格	价格	库存
5 mg	￥2280	In stock
10 mg	￥3480	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Ifebemtinib (BI 853520, IN10018) is potent, highly selective and orally active inhibitor of PTK2/FAK with IC50 of 1 nM in cell-free assays.
BI 853520 inhibits only 4 enzymes at 10 uM in a panel of 264 tyrosine and serine/threonine kinases.
BI 853520 inhibits the colony formation of PC-3 cells with EC50 of 3 nM.
BI 853520 suppresses PTK2 autophosphorylation in tissue samples from both human tumor xenografts and mouse skin.
BI 853520 demonstrates anti-tumor activity in vivo.

物理化学性质&存储条件

分子量	588.56
分子式	C28H28F4N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-fluoro-5-methoxy-4-((4-((2-methyl-3-oxoisoindolin-4-yl)oxy)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide

参考文献

1. Roy-Luzarraga M, et al. Clin Cancer Res. 2016 Aug 1;22(15):3718-24.

BI-853520 (Ifebemtinib, BI 853520, IN10018)

生物&药学活性

物理化学性质&存储条件

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BI-853520 (Ifebemtinib, BI 853520, IN10018)

生物&药学活性

物理化学性质&存储条件

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